12号染色体开放阅读框53抗体
规格：1mg/1ml
英文名： C12ORF53
别名： Chromosome 12 open reading frame 53; DKFZp547D2210; Hypothetical protein LOC196500; Uncharacterized protein C12orf53; PIANP_HUMAN.
分子量： 27kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human C12ORF53
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
细胞定位：细胞膜
12号染色体开放阅读框53抗体产品介绍：background: Encoding over 1,100 genes within 132 million bases, chromosome 12 makes up about 4.5% of the human genome. A number of skeletal deformities are linked to chromosome 12 including hypochondrogenesis, achondrogenesis and Kniest dysplasia. Noonan syndrome, which includes heart and facial developmental defects among the primary symptoms, is caused by a mutant form of PTPN11 gene product, SH-PTP2. Chromosome 12 is also home to a homeobox gene cluster which encodes crucial transcription factors for morphogenesis, and the natural killer complex gene cluster encoding C-type lectin proteins which mediate the NK cell response to MHC I interaction. Trisomy 12p leads to facial development defects, seizure disorders and a host of other symptoms varying in severity 12号染色体开放阅读框53抗体depending on the extent of mosaicism and is most severe in cases of complete trisomy. The C12orf53 gene product has been provisionally designated C12orf53 pending further characterization. Function: Acts as a ligand for PILRA in neural tissues, where it may be involved in immune regulation. Subcellular Location: Membrane; single pass type I membrane protein Tissue Specificity: Mainly expressed in 12号染色体开放阅读框53抗体***** brain and cerebellum. Weaker expression in fetal brain and virtually no expression in spleen, heart, kidney, liver and dorsal ganglion relative to brain. Post-translational modifications: O-glycosylation at Thr-140 is essential for recognition by PILRA (By similarity). Database links: Entrez Gene: 196500 Human SwissProt: Q8IYJ0 Human SwissProt: Q6P1B3 Mouse SwissProt: Q5U2P6 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
12号染色体开放阅读框53抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid