皮肤T细胞**瘤相关抗原5抗体
规格：1mg/1ml
英文名： CTAGE5
别名： cTAGE 5A; cTAGE 5B; cTAGE 5C; cTAGE 5D; cTAGE family member 5; CTAGE family, member 5; CTAGE5; cTAGE5A; cTAGE5B; cTAGE5C; cTAGE5D; CTGE5_HUMAN; Cutaneous T cell lymphoma associated antigen 5; Cutaneou
分子量： 91kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CTAGE5 (
交叉反应：Human,
细胞定位：
皮肤T细胞**瘤相关抗原5抗体产品介绍：background: Cutaneous T cell lymphomas (CTCL) represent a group of malignancies that originate from CD4-T lymphocytes and manifest on the skin. CTCL is a general term for several neoplasms including mycosis fungoides, T cell leukemia/ lymphoma and pagetoid reticulosis, all of which are very difficult to treat in the advanced stages. CTAGE2 (cutaneous T cell lymphoma associated-antigen 2) is a member of the cancer/testis antigen family of proteins (CTAGE) that, under normal conditions, are found primarily in the testis with little or no expression in other parts of the body. Another member of the CTAG family, namely CTAGE5 (also known as MEA11, MEA6, MGEA11 or MGEA6), is a tumor associated antigen that is found in tumors of various origins, including cutaneous T cell lymphomas. Both CTAGE2 and CTAGE5 are expressed as multiple isoforms due to alternative splicing events. Function: Tumor-associated antigen.Tissue specificity:Isoform 5A is expressed only in testis (at the protein level). Other isoforms are expressed in several other normal tissues, including brain, muscle and cranial skin. Isoform 5A (at protein level) and isoform 5B are expressed in cutaneous T-cell lymphoma (CTCL) cell lines, colorectal carcinomas, 皮肤T细胞**瘤相关抗原5抗体breast carcinomas and melanoma. Isoform 5B, but not isoform 5A, is expressed in head and neck squamous cell carcinoma. Tissue Specificity: Isoform 5A is expressed only in testis (at the protein level). Other isoforms are expressed in several other normal tissues, including brain, muscle and cranial skin. Isoform 5A (at protein level) and isoform 5B are expressed in cutaneous T-cell lymphoma (CTCL) cell lines, colorectal carcinomas, breast carcinomas and melanoma. Isoform 5B, but not isoform 5A, is expressed in head and neck squamous cell carcinoma. DISEASE: Note=Autoantibodies against CTAGE5 are present in several cancer types, including benign meningioma and cutaneous T-cell lymphoma (CTCL)皮肤T细胞**瘤相关抗原5抗体. Similarity: Belongs to the cTAGE family. Gene ID: 4253 Database links: Entrez Gene: 4253 Human Omim: 602132 Human SwissProt: O15320 Human Unigene: 509200 Human Unigene: 540038 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
皮肤T细胞**瘤相关抗原5抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 **细胞 t-**细胞 肿瘤细胞生物标志物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid