顺氯氨铂耐药相关蛋白9抗体
规格：1mg/1ml
英文名： CRR9
别名： Cisplatin resistance related protein 9; Cisplatin resistance related protein CRR9p; Cisplatin resistance-related protein 9; Cleft lip and palate transmembrane protein 1 like protein; Cleft lip and pal
分子量： 62kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CLPTM1L/
交叉反应：Human, Mouse, Rat, Dog, Horse,
细胞定位：细胞膜
顺氯氨铂耐药相关蛋白9抗体产品介绍：background: Clefts of the oral-facial region usually occur in early fetal development and can affect the lip, the soft palate and the hard palate. Cleft lip (with or without cleft palate) is a genetically complex birth defect that occurs in approximately one in every 750-1,000 live births. This is one of the most common birth defects and is multifactorial, with both genetic and environmental causes. Cleft lip- and palate-associated transmembrane protein 1 (CLPTM1) belongs to a family of cleft lip and palate transmembrane proteins. This family also contains cisplatin resistance-related protein (CRR9), which is involved in CDDP-induced apoptosis. CLPTM1L (cleft lip and palate transmembrane protein 1-like protein), also known as CRR9p (cisplatin resistance-related protein 9) is a 538 amino acid multi-pass membrane protein that belongs to the CLPTM1 family and, when overexpressed, enhances cisplatin-mediated apoptosis. CLPTM1L exists as two alternatively顺氯氨铂耐药相关蛋白9抗体 spliced isoforms encoded by a gene that maps to human chromosome 5p15.33. Function: Enhances cisplatin-mediated apoptosis, when overexpressed. Subcellular Location: Membrane; Multi-pass membrane protein (Potential). Similarity: Belongs to the CLPTM1 family Gene ID: 81037 Database links: Entrez Gene: 81037 Human Omim: 612585 Human SwissProt: 顺氯氨铂耐药相关蛋白9抗体Q96KA5 Human Unigene: 444673 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 顺氯氨铂属于细胞周期非特异**物，具有细胞毒性，可抑制癌细胞的DNA复制过程，并损伤其细胞膜上结构，有较强的广谱**作用。临床用于卵巢癌、前列腺癌、睾丸癌、肺癌、鼻咽癌、食道癌、恶性**瘤、乳腺癌、头颈部鳞癌、甲状腺癌及成骨肉瘤等多种实体肿瘤均能显示疗效。
顺氯氨铂耐药相关蛋白9抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 细胞凋亡
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid