磷酸化丝裂原活化蛋白激酶3K9抗体
规格：1mg/1ml
英文名： phospho-MAP3K9+MAP3K10(Thr312 + Thr266)
别名： MAP3K9 +MAP3K10 (phospho T312 + T266); MAP3K9 + MAP3K10(phospho T312 + T266); phospho-MAP3K9(Thr312)/MAP3K10( Thr266); p-MAP3K9; M3K9_HUMAN; M3K10_HUMAN; MAPKKK9; MEKK10; MEKK9; Mitogen activated prot
分子量： 121/105kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthesised phosphopeptide derived from human
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：
磷酸化丝裂原活化蛋白激酶3K9抗体产品介绍：background: The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. [provided by RefSeq, Jul 2008]. Function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. 磷酸化丝裂原活化蛋白激酶3K9抗体Subunit: Homodimer. Tissue Specificity: Expressed in epithelial tumor cell lines of colonic, breast and esophageal origin. Post-translational modifications: Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-312 is likely to be the main autophosphorylation site. Autophosphorylation also occurs on Thr-304 and Ser-308. DISEASE: May play a role in esophageal cancer susceptibility and/or development. Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family磷酸化丝裂原活化蛋白激酶3K9抗体. MAP kinase kinase kinase subfamily. Contains 1 protein kinase domain. Contains 1 SH3 domain. Gene ID: 4293 Database links: Entrez Gene: 4293 Human Entrez Gene: 4294 Human Entrez Gene: 269881 Mouse Entrez Gene: 338372 Mouse Omim: 600136 Human Omim: 600137 Human SwissProt: P80192 Human SwissProt: Q02779 Human SwissProt: Q3U1V8 Mouse SwissProt: Q66L42 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
磷酸化丝裂原活化蛋白激酶3K9抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid