载脂蛋白B-mRNA编码蛋白抗体
规格：1mg/1ml
英文名： A1CF
别名： A1CF; A1CF_HUMAN; ACF; ACF64; ACF65; Apo B RNA editing protein; Apobec 1 complementation factor; Apobec 1 complementation factor (ACF) (ASP); APOBEC 1 stimulating protein; APOBEC1 complementation fact
分子量： 65kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human A1CF
交叉反应：Human, Mouse, Rat, Pig, Cow, Sheep,
细胞定位：细胞核 细胞浆
载脂蛋白B-mRNA编码蛋白抗体产品介绍：background: Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay. Function: Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the posttranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay. Subunit: Part of the apolipoprotein B mRNA editing complex with 载脂蛋白B-mRNA编码蛋白抗体APOBEC1. Interacts with TNPO2; TNPO2 may be responsible for transport of A1CF into the nucleus. Interacts with SYNCRIP. Interacts with CELF2/CUGBP2. Subcellular Location: Nucleus. Endoplasmic reticulum. Cytoplasm. Note=Predominantly nuclear where it localizes to heterochromatin. Also cytoplasmic where it is found at the outer surface of the endoplasmic reticulum. Shuttles between the nucleus and cytoplasm. May be transported into the nucleus by the nuclear import protein TNPO2/TRN2 or by APOBEC1. Tissue Specificity: Widely expressed with highest levels in brain, liver, pancreas, colon and spleen. Similarity: Contains 3 RRM (RNA recognition motif) domains. Gene ID: 29974 Database载脂蛋白B-mRNA编码蛋白抗体links: Entrez Gene: 29974 Human Entrez Gene: 69865 Mouse Entrez Gene: 170912 Rat SwissProt: Q9NQ94 Human SwissProt: Q5YD48 Mouse SwissProt: Q923K9 Rat Unigene: 282795 Human Unigene: 87538 Mouse Unigene: 162520 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
载脂蛋白B-mRNA编码蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid