富含亮氨酸重复结构域蛋白2抗体
规格：1mg/1ml
英文名： NALP2
别名： CLR19.9; FLJ20510; Leucine rich repeat and PYD containing protein 2; LRR and PYD domains-containing protein 2; NACHT; NACHT domain; NACHT leucine rich repeat and PYD containing 2; NACHT LRR and PYD do
分子量： 117kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NACHT, L
交叉反应：Human, Mouse, Rat, Horse, Rabbit,
细胞定位：
富含亮氨酸重复结构域蛋白2抗体产品介绍：background: NALP proteins, such as NALP2, are characterized by an N-terminal pyrin (MIM 608107) domain (PYD) and are involved in the activation of caspase-1 (CASP1; MIM 147678) by Toll-like receptors (see TLR4; MIM 603030). They may also be involved in protein complexes that activate proinflammatory caspases (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008]. Function: Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function富含亮氨酸重复结构域蛋白2抗体 would be the activation of proinflammatory caspases. Subunit: Interacts with CHUK, IKBKB and IKBKG, as well as with full-length PYCARD and with the DAPIN domain of NAPL1, but not the full-length protein. Subcellular Location:富含亮氨酸重复结构域蛋白2抗体 Cytoplasm. Tissue Specificity: Expressed at high levels in lung, placenta and thymus and at lower levels in ovary, intestine and brain. Similarity: Belongs to the NLRP family. Contains 1 DAPIN domain. Contains 8 LRR (leucine-rich) repeats. Contains 1 NACHT domain. Database links: UniProtKB/Swiss-Prot: Q9NX02.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
富含亮氨酸重复结构域蛋白2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞凋亡
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid