色氨酸相关蛋白3抗体
规格：1mg/1ml
英文名： TRPC3
别名： Htrp 3; Htrp3; MGC124333; Mtrp3; Receptor activated cation channel TRP3v Short transient receptor potential channel 3; Transient receptor potential cation channel subfamily C member 3; Transient recep
分子量： 92kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TRPC3
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：细胞膜
色氨酸相关蛋白3抗体产品介绍：background: TRPC channels form the subfamily of channels in human most closely related to drosophila TRP channels. Structurally, this family shares a number of similar characteristics. At the proximal C-terminus of this sub-family is a TRP box motif containing the invariant EWKFAR sequence and between 3 and 4 ankyrin repeats near the N-terminus. These channels are non-selectively permeable to cations, with a selectivity of calcium over sodium variable among the different members. Many of TRPC channel subunits are able to coassemble. Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in色氨酸相关蛋白3抗体 a membrane-delimited fashion, independently of protein kinase C, and by inositol-1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion. Subunit: Interacts with TRPC1, ITPR1, ITPR3, MX1 and RNF24. Interacts with JPH2; the interaction is involved in maintaining Ca(2+) homeostasis in skeletal muscle and is mediated by JPH2 'Ser-165' phosphorylation. Subcellular Location: Cell Membrane; multi-pass membrane protein Tissue Specificity: Expressed predominantly in brain and at much lower levels in 色氨酸相关蛋白3抗体ovary, colon, small intestine, lung, prostate, placenta and testis. Similarity: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC3 sub-subfamily. Contains 4 ANK repeats. Database links: UniProtKB/Swiss-Prot: Q13507.3 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
色氨酸相关蛋白3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 神经生物学 信号转导 转录调节因子 结合蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid