钠通道蛋白10α抗体
规格：1mg/1ml
英文名： SCN10A/Nav1.8
别名： mPN3; Peripheral nerve sodium channel 3; Pn3 (gene name)v PN3; Scn10a; Sensory neuron sodium channel; Sns (gene name); SNS; sodium channel protein type 10 subunit alpha; Sodium channel protein type X
分子量： 215kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SCN10A/N
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow,
细胞定位：细胞膜 细胞外基质
钠通道蛋白10α抗体产品介绍：background: Nav1.8 protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, Nav1.8 forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Nav1.8 plays a role in neuropathic pain mechanisms. Function: This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Its electrophysiological properties vary depending on the type of the associated beta subunits (in vitro). Plays a role in neuropathic pain mechanisms. Subunit: The voltage-resistant sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or钠通道蛋白10α抗体 more associated auxiliary subunits SCN1B, SCN2B and SCN3B. Found in a number of complexes with PRX, DYNLT1 and PDZD2. Interacts with proteins such as FSTL1, PRX, DYNLT1, PDZD2, S100A10 and many others. Interacts with NEDD4 and NEDD4L. Subcellular Location: Membrane; Multi-pass membrane protein. Note=It can be translocated to the extracellular membrane through association 钠通道蛋白10α抗体with S100A10. Tissue Specificity: Expressed in the dorsal root ganglia and sciatic nerve. Post-translational modifications: Ubiquitinated by NEDD4L; which promotes its endocytosis. Similarity: Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily. Contains 1 IQ domain. Database links: Entrez Gene: 6336 Human Entrez Gene: 20264 Mouse Entrez Gene: 29571 Rat Omim: 604427 Human SwissProt: Q9Y5Y9 Human SwissProt: P70276 Mouse SwissProt: Q6QIY3 Mouse SwissProt: Q62968 Rat Unigene: 250443 Human Unigene: 10246 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
钠通道蛋白10α抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 通道蛋白 细胞膜受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid