M钙粘附分子抗体
规格：1mg/1ml
英文名： M Cadherin
别名： M-Cadherin; Cadherin 14; Cadherin 15; Cadherin 3; Cadherin14; Cadherin15; Cadherin3; CCAD; CDH 14; CDH 15; CDH 3; CDH14; CDH15; CDH3; CDHM; MCAD; Muscle cadherin; Myotubule cadherin; CAD15_HUMAN.
分子量： 89kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human M-Cadher
交叉反应：Human, Mouse, Rat, Dog, Cow,
细胞定位：细胞膜
M钙粘附分子抗体产品介绍：background: Cadherins are a family of transmembrane glycoproteins that play a key role in Calcium dependent cell-cell adhesion. Several members of the cadherin family have been identified so far, including E- (epithelial), P- (placental), N- (neuronal) and M- (muscle) cadherin. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in myoblasts and upregulated in myotubule-forming cells. M-Cadherin is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation. Function: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in aM钙粘附分子抗体 homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation. Subcellular Location: Type 1 membrane protein. Tissue Specificity: Expressed in the brain and cerebellum. DISEASE: Note=A chromosomal aberration involving CDH15 and KIRREL3 is found in aM钙粘附分子抗体 patient with severe mental retardation and dysmorphic facial features. Translocation t(11;16)(q24.2;q24). Defects in CDH15 are the cause of mental retardation autosomal dominant type 3 (MRD3) [MIM:612580]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Similarity: Contains 5 cadherin domains. Database links: UniProtKB/Swiss-Prot: P55291.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
M钙粘附分子抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导 细胞粘附分子 细胞表面分子 细胞膜蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid