2号染色体开放阅读框6抗体
规格：1mg/1ml
英文名： C2orf6/MOBK1B
别名： C2orf6; Chromosome 2 open reading frame 6; MATS1; MOB1; Mob1 alpha; Mob1 homolog 1B; MOB1 Mps One Binder kinase activator like 1B; Mob1A; MOB4B; Mob4B protein; MOBKL1B; MOBK1B; MOL1B_HUMAN; Mps one bi
分子量： 25kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MOBK1B/C
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：
2号染色体开放阅读框6抗体产品介绍：background: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Function: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the 2号染色体开放阅读框6抗体nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38. Subunit: Binds STK38 and STK38L. Interacts with LATS1 and LATS2. Forms a tripartite complex with STK38 and STK3/MST2. Tissue Specificity: Adrenal gland, bone marrow, brain, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, heart, spinal cord, fetal brain and fetal liver. Post-translational modifications: Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1. Similarity: Belongs to the MOB1/phocein family. Database links: Entrez 2号染色体开放阅读框6抗体Gene: 55233 Human Entrez Gene: 232157 Mouse Entrez Gene: 100366014 Rat Entrez Gene: 297387 Rat Omim: 609281 Human SwissProt: Q9H8S9 Human SwissProt: Q921Y0 Mouse SwissProt: Q3T1J9 Rat Unigene: 29500 Mouse Unigene: 74475 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
2号染色体开放阅读框6抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 信号转导 干细胞 激酶和磷酸酶 肿瘤细胞生物标志物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid