候选肿瘤抑制基因MARVELD1抗体
规格：1mg/1ml
英文名： MARVELD1
别名： GB14; MARVD1; MARVEL (membrane-associating) domain containing 1; MARVEL domain containing protein 1; MRVLDC1; Putative MARVEL domain containing protein 1; MALD1_HUMAN.
分子量： 19kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MARVELD1
交叉反应：Human, Mouse, Rabbit,
细胞定位：细胞核 细胞浆 细胞膜
候选肿瘤抑制基因MARVELD1抗体产品介绍：background: MARVELD1, (MARVEL domain-containing 1), is one of the MARVEL (MAL and related proteins for vesicle trafficking and membrane link) domain-containing proteins. It is a nuclear-localized protein that is widely expressed in normal human tissues. While it has been reported to be overexpressed in colon cancer, MARVELD1 protein levels are generally lower in several primary tumors including ovary, breast, kidney, bladder and liver. This lower level of MARVELD1 expression in tumors is thought to be due to a higher methylation status of the MARVELD1 promoter as treatment of MDA-MB-361 with 5-aza-2'-deoxycytidine restores MARVELD1 expression, suggesting that loss of MARVELD1 expression may contribute to tumorgenicity. Function: Microtubule-associated protein that 候选肿瘤抑制基因MARVELD1抗体exhibits cell cycle-dependent localization and can inhibit cell proliferation and migration Subcellular Location: Cell membrane; Multi-pass membrane protein. Cytoplasm, cytoskeleton. Nucleus. Note=Observed in the nucleus and at the perinuclear region during interphase, but localizes at the mitotic spindle and midbody at metaphase. A significant fraction of MARVELD1 translocates to the候选肿瘤抑制基因MARVELD1抗体 plasma membrane during anaphase or upon microtubule depolymerization. Tissue Specificity: Widely expressed in normal tissues. Down-regulated in multiple primary tumors. Similarity: Contains 1 MARVEL domain. Database links: UniProtKB/Swiss-Prot: Q9BSK0.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
候选肿瘤抑制基因MARVELD1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 肿瘤细胞生物标志物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid