癌基因RAS相关蛋白Rab25抗体
规格：1mg/1ml
英文名： Rab25
别名： CATX 8; CATX-8; CATX8; member RAS oncogene family; RAB25; RAB-25; RAB25_HUMAN; Ras related protein Rab 25; Ras-related protein Rab-25.
分子量： 23kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Rab25 (1
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞浆 细胞膜
癌基因RAS相关蛋白Rab25抗体产品介绍：background: RAB proteins, such as RAB25, are members of the RASsuperfamily of small GTPases that are involved in membranetrafficking. Members of the RAB11 subfamily, including RAB25,control the return of internalized membrane-associated moieties tothe cell surface Function: Involved in the regulation of cell survival. Promotesinvasive migration of cells in which it functions to localize andmaintain integrin alpha-V/beta-1 at the tips of extendingpseudopodia. Increases the rates of ovarian and breast cancersprogression and aggressiveness by modulating cellular processessuch as proliferation, survival and migration of epithelial tumorcells. May selectively regulate the apical recycling pathway.Together with MYO5B regulates transcytosis Subunit: Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3癌基因RAS相关蛋白Rab25抗体 andRAB11FIP4. Interacts (via the hypervariable C-terminal region) withITGB1 (via the cytoplasmic region); the interaction isGTP-dependent. Interacts with ITGAV. Associates with the integrinalpha-V/beta-1 heterodimer. Subcellular Location: Cell membrane; Lipid-anchor; Cytoplasmicside (Potential). Cell projection, pseudopodium membrane.Cytoplasmic vesicle. Note=Colocalizes with integrin alpha-V/beta-1in vesicles at the pseudopodial tips. Tissue Specificity: Expressed in ovarian epithelium (NOE) andbreast tissue. Expressed in ovarian cancer; expression is 癌基因RAS相关蛋白Rab25抗体increasedrelative to NOE cells. Expression in ovarian cancer is stagedependent, with stage III and stage IV showing higher levels thanearly stage cancers. Expressed in breast cancer; expression isincreased relative to normal breast tissue. Similarity: Belongs to the small GTPase superfamily. Rab family. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
癌基因RAS相关蛋白Rab25抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 信号转导 转录调节因子 肿瘤细胞生物标志物 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid