5-三磷酸肌醇受体3抗体
规格：1mg/1ml
英文名： ITPR3
别名： IP3R-III; IP3 receptor isoform 3; 4 antibody 5-trisphosphate receptor; 5-trisphosphate receptor type 3; FLJ36205; Inositol 1; Inositol 1,4,5 trisphosphate receptor type 3; IP3 receptor; IP3R 3; IP3R;
分子量： 294kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ITPR3
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, d
细胞定位：细胞浆 细胞膜
5-三磷酸肌醇受体3抗体产品介绍：background: Inositol 1,4,5-triphosphate (IP3) functions as a second messenger for a myriad of extracellular stimuli including hormones, growth factors and neurotransmitters. Receptor tyrosine kinases indirectly increase the intracellular levels of IP3 through the activation of phospholipases such as phospholipase C (PLC), which convert phosphatidylinositol-4,5 bisphosphate into IP3 and diacylglycerol (DAG). The inositol 1,4,5-triphosphate receptor, IP3R, acts as an inositol triphosphate (IP3)-gated calcium release channel in a variety of cell types. Three IP3 receptor subtypes have been described and are designated IP3R-I, IP3R-II and IP3R-III. IP3R-I is the predominant IP3R subtype expressed in neuronal tissues and the central nervous system, but is also expressed at high levels in the liver. Function: Transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig 5-三磷酸肌醇受体3抗体secreting cells. Subunit: Homotetramer. Interacts with SIGMAR1, PML, AKT1, TRPC1, TRPC3 and TRPC4 (By similarity). Interacts with CABP1. Interacts with TMBIM4/LFG4. Subcellular Location: Endoplasmic reticulum membrane. Tissue Specificity: Expressed in intestinal crypt and villus epithelial cells. Similarity: Belongs to the InsP3 receptor family. Contains 5 MIR domains. Database links:5-三磷酸肌醇受体3抗体 Entrez Gene: 317697 Cow Entrez Gene: 3708 Human Entrez Gene: 16438 Mouse Entrez Gene: 25262 Rat Omim: 147265 Human SwissProt: Q9TU34 Cow SwissProt: Q14643 Human SwissProt: P11881 Mouse SwissProt: P29994 Rat Unigene: 567295 Human Unigene: 715765 Human Unigene: 227912 Mouse Unigene: 2135 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品5-三磷酸肌醇受体3抗体应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 神经生物学 信号转导 生长因子和**
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid