含半胱氨酸和组氨酸丰富域蛋白1抗体
规格：1mg/1ml
英文名： CHORDC1
别名： CHORD containing protein 1; Chord domain containing protein 1; CHORD domain-containing protein 1; CHORD-containing protein 1; CHORDC1; CHP-1; CHP1; CHRD1_HUMAN; Cysteine and histidine rich domain (CHO
分子量： 37kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CHORDC1
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：
含半胱氨酸和组氨酸丰富域蛋白1抗体产品介绍：background: Human CHP1 and the C. elegans homolog Chp are CHORD domain-containing proteins that are largely related, and their corresponding genes are evolutionarily conserved among various eukaryotic organisms (1,2). The unique CHORD domain is characterized as 60 amino acids in length, and contains six highly conserved cysteine residues, two histidine residues and a distinct Zn2+-binding domain (3). CHP1 and the other metazoan orthologs have tandem CHORD domains that are located at both the N- and C- termini (1,4). These proteins are implicated in germline development and embryogenesis as mutations affecting the CHORD domain of the nematode protein Chp result in semisterility and embryonic lethality (1,5). Function: Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone含半胱氨酸和组氨酸丰富域蛋白1抗体 complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis. Subunit: InteractswithHSP90AA1,ROCK1andROCK2.InteractswithHSP90AB1andPPP5C Tissue Specificity: Underexpressedinmanybreastandlungcancers. Similarity: Contains2CHORDdomains. Contains1CSdomain. Database links: Entrez Gene: 26973 Human Entrez Gene: 66917 Mouse Entrez Gene: 315447 Rat Omim: 604353 含半胱氨酸和组氨酸丰富域蛋白1抗体Human SwissProt: Q9UHD1 Human SwissProt: Q9D1P4 Mouse SwissProt: D4A4T9 Rat Unigene: 22857 Human Unigene: 479183 Mouse Unigene: 6136 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
含半胱氨酸和组氨酸丰富域蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid