生长抑制蛋白NDN抗体
规格：1mg/1ml
英文名： Necdin
别名： HsT16328; NDN; NECD_HUMAN; Necdin; Necdin homolog.
分子量： 36kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Necdin
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核
生长抑制蛋白NDN抗体产品介绍：background: This intronless gene is located in the Prader-Willi syndrome deletion region. It is an imprinted gene and is expressed exclusively from the paternal allele. Studies in mouse suggest that the protein encoded by this gene may suppress growth in postmitotic neurons. Function: Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific guanosine-rich DNA sequences. Subunit: Binds to the transactivation domains of E2F1 and p53. Binds also 生长抑制蛋白NDN抗体SV40 large T antigen and adenovirus E1A. Interacts with nucleobindin 1 and 2 Subcellular Location: Perikaryon. Nucleus. Neural perikarya, translocates to the nucleus of postmitotic neurons and interacts with the nuclear matrix. Tissue Specificity: Almost ubiquitous. Detected in fetal brain, lung, liver and kidney; in ***** heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine and colon. Not detected in peripheral blood leukocytes. In brain, restricted to post-mitotic neurons. Similarity: Contains 1 MAGE domain.生长抑制蛋白NDN抗体 Gene ID: 4692 Database links: Entrez Gene: 4692 Human Entrez Gene: 17984 Mouse Entrez Gene: 308690 Rat Omim: 602117 Human SwissProt: Q99608 Human SwissProt: P25233 Mouse Unigene: 50130 Human Unigene: 400253 Mouse Unigene: 3096 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
生长抑制蛋白NDN抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 细胞周期蛋白 细胞类型标志物 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid