E1A样分化抑制因子3抗体
规格：1mg/1ml
英文名： EID3
别名： E1A-like inhibitor of differentiation 3; EID 3; EID-1-like inhibitor of differentiation 3; EID-3; EID3; EID3_HUMAN; EP300 interacting inhibitor of differentiation 3; EP300-interacting inhibitor of dif
分子量： 38kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human EID3
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Sheep,
细胞定位：细胞核 细胞浆
E1A样分化抑制因子3抗体产品介绍：background: Act as a repressor of nuclear receptor-dependent transcription possibly by interfering with CREBBP-dependent coactivation. May function as a coinhibitor of other CREBBP/EP300-dependent transcription factors.Tissue specificity: Highly expressed in testis. Function: Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Acts as a repressor of nuclear receptor-dependent transcription possibly by interfering with E1A样分化抑制因子3抗体CREBBP-dependent coactivation. May function as a coinhibitor of other CREBBP/EP300-dependent transcription factors. Subunit: Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NDNL2; EID3 seems to be a testis-specific subunit. NSMCE1, NSMCE4A or EID3 and NDNL2 probably form a subcomplex that bridges the head domains of the SMC5:SMC6 heterodimer. Homodimer, and heterodimer with EID2 (By similarity). Interacts with the C-terminal region of CREBBP. Subcellular Location: Nucleus. Cytoplasm. Chromosome, telomere (Probable). Note=May shuttle between nucleus and cytoplasm. Tissue Specificity: Highly expressed in testis. Similarity: Belongs to the NSE4 family. Gene ID: 493861 Database links: Entrez Gene: 493861 Human Entrez Gene: 66341 Mouse Entrez Gene:E1A样分化抑制因子3抗体 691688 Rat Omim: 612986 Human SwissProt: Q8N140 Human SwissProt: Q3V124 Mouse SwissProt: Q4V8G2 Rat Unigene: 659857 Human Unigene: 443284 Mouse Unigene: 206488 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
E1A样分化抑制因子3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞周期蛋白 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid