载脂蛋白B受体抗体
规格：1mg/1ml
英文名： APOB48R
别名： apo b-100; APOB; apoB-48R; apoB-100R; apoB100R; Apolipoprotein B-100 receptor; Apolipoprotein B100 receptor; Apolipoprotein B48 receptor; APOBR_HUMAN.
分子量： 115kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human APOB48R
交叉反应：Human, Mouse, Rat, Dog, Rabbit,
细胞定位：细胞膜
载脂蛋白B受体抗体产品介绍：background: APOB48R is a macrophage receptor that binds to the apolipoprotein B48 of dietary triglyceride (TG) rich lipoproteins. It may provide essential lipids, lipid soluble vitamins and other nutrients to reticuloendothelial cells. Function: Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevated TRL and remnant lipoprotein (RLP). Mediates the rapid high-affinity uptake of chylomicrons (CM), HTG-VLDL, and trypsinized (tryp) VLDL devoid of APOE in vitro in macrophages. Subunit: Homodimer. Subcellular Location: Cell membrane; Peripheral membrane protein. Note=Binds monocyte-macrophage membrane. Thought to 载脂蛋白B受体抗体be anchored in the membrane through an interaction with an integral membrane protein. Tissue Specificity: Expressed in peripheral blood leukocytes > bone marrow = spleen > lymph node, and only faintly visible in appendix and thymus. Expressed in the brain, heart, kidney, liver, lung, pancreas, and placenta. Expressed primarily by reticuloendothelial cells: monocytes, macrophages, and endothelial cells. Expressed in atherosclerotic lesion foam cells. Post-translational modifications: There are 2 forms in macrophages, the membrane-binding proteins 载脂蛋白B受体抗体200 kDa (MBP 200) and 235 kDa (MBP 235), that can be reduced into a single active ligand-binding species with intermediate mobility (MBP 200R). Gene ID: 55911 Database links: Entrez Gene: 55911 Human Entrez Gene: 171504 Mouse Omim: 605220 Human SwissProt: Q0VD83 Human SwissProt: Q8VBT6 Mouse Unigene: 200333 Human Unigene: 170665 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
载脂蛋白B受体抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 细胞生物 **学 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid