C末端结合蛋白2抗体
规格：1mg/1ml
英文名： CTBP2
别名： C-terminal-binding protein 2 isoform 1; C terminal binding protein 2; C-terminal-binding protein 2; CtBP2; CTBP2_HUMAN; ribeye.
分子量： 53kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CTBP2
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit,
细胞定位：细胞核 细胞膜
C末端结合蛋白2抗体产品介绍：background: This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]. Function: Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation. Isoform 2 probably acts as a scaffold for specialized synapses. Subunit: Interacts with the C-terminus of adenovirus E1A protein. Can form homodimers or C末端结合蛋白2抗体heterodimers of CTBP1 and CTBP2. Interacts with HIPK2 and ZNF217. Interacts with PRDM16; represses white adipose tissue (WAT)-specific genes expression. Interacts with PNN, NRIP1 and WIZ. Subcellular Location: Nucleus. Cell junction, synapse. Tissue Specificity: Ubiquitous. Highest levels in heart, skeletalv muscle, and pancreas. Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. Gene ID: 1488 Database links: Entrez Gene: 281730 Cow Entrez Gene: 1488 Human Entrez Gene: 13017 Mouse Entrez Gene: 81717 Rat Omim: 602619 Human SwissProt: Q0VCQ1 Cow SwissProt: P56545 Human SwissProt: P56546 Mouse SwissProt: Q9EQH5 Rat Unigene: 501345 Human Unigene: C末端结合蛋白2抗体246240 Mouse Unigene: 389984 Mouse Unigene: 138124 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
C末端结合蛋白2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid