WASF2抗体
规格：1mg/1ml
英文名： WASF2
别名： Protein WAVE-2; SCAR 2; SCAR; SCAR2; Verprolin homology domain-containing protein 2; WASF2; WASF2_HUMAN; WASP family protein member 2; WASP-family protein member 2; WAVE 2; WAVE2; Wiskott-Aldrich synd
分子量： 54 kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human WASF2
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Sheep,
细胞定位：细胞浆 细胞膜
WASF2抗体产品介绍：background: This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location (PMID:10381382) has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X. Two transcript variants encoding different isoforms have been found for this gene. Function: Downstream effector molecule involved in the transmission of signals from tyrosine kinaseWASF2抗体 receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Subunit: Binds actin and the Arp2/3 complex. Interacts with BAIAP2. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2. Directly interacts with BRK1. Subcellular Location: Cytoplasm, cytoskeleton (By similarity). Cell projection, lamellipodium (By similarity). Note=At WASF2抗体the interface between the lamellipodial actin meshwork and the membrane Tissue Specificity: Expressed in all tissues with strongest expression in placenta, lung, and peripheral blood leukocytes, but not in skeletal muscle. Similarity: Belongs to the SCAR/WAVE family. Contains 1 WH2 domain. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
WASF2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid