CD2结合蛋白3抗体
规格：1mg/1ml
英文名： CD2BP3
别名： Cbl interacting protein; Cbl interacting protein of 85 kDa; CD2 binding protein 3; CD2BP3; CIN 85; CIN85; GIG 10; GIG10; HSB 1; Human Src family kinase binding protein 1; MIG 18; MIG18; Migration indu
分子量： 73kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SH3KBP1/
交叉反应：Human, Mouse, Rat, Chicken, Cow, Rabbit, Sheep,
细胞定位：细胞浆 细胞膜
CD2结合蛋白3抗体产品介绍：background: SH3KBP1 belongs to the CIN85/CMS family of adaptor molecules, characterized by containing three N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The different members of the family orchestrate a network involved in dowregulation and degradation of recpetor tyrosine kinases. SH3KBP1 is involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. In the case of EGF receptor turnover, its activation involves recruitment of SH3KBP1- endophilin complexes to mediate internalization. Once internalized, RTKs are delivered into the endosomal compartment where receptors get sorted for either recycling back to the cell surface or are targeted to lysosomes for degradation. Alternate splicing results in multiple transcript variants. Function: Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through CD2结合蛋白3抗体a association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Subunit: Contains 3 SH3 domains. Subcellular Location: Cytoplasm > cytoskeleton. CD2结合蛋白3抗体Cytoplasmic vesicle membrane. Cell junction > synapse > synaptosome. Cell junction > focal adhesion. Localized in endocytic vesicles containing clustered receptors. Colocalizes with ASAP1 in vesicular structures. Colocalized with actin microfilaments and focal adhesions (By similarity). Colocalized with MAGI2 in synaptosomes. Tissue Specificity: Ubiquitously expressed. Also expressed in some cancer cell lines. Post-translational modifications: Monoubiquitinated by CBL and CBLB after EGF stimulation; probably on its C-terminus. Similarity: Contains 3 SH3 domains. Database links: UniProtKB/Swiss-Prot: Q96B97.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产CD2结合蛋白3抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid