膜相关的蛋白质HEM2抗体
规格：1mg/1ml
英文名： NCKAP1
别名： NCK associated protein 1; NCK associated protein 1; Membrane associated protein HEM2; Membrane-associated protein HEM-2; NAP 1; NAP1; NAP125; NCK associated protein; Nck-associated protein 1; Nckap1;
分子量： 129kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human 12 NCKAP
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Guinea Pig, G
细胞定位：细胞膜
膜相关的蛋白质HEM2抗体产品介绍：background: NAP125, also known as NCKAP1 (NCK-associated protein 1), p125Nap1 or membrane-associated protein HEM-2, is a 1,128 amino acid single pass membrane protein that exists as two alternatively spliced isoforms and belongs to the HEM-1/HEM-2 family. While widely expressed, NAP125 is found at highest levels in heart, brain and skeletal muscle where it regulates Rac-dependent actin remodeling as part of a lamellipodial complex with WAVE2, Abi-1 and CYFIP1. NAP125 localizes to the cytoplasmic side of lamellipodium membrane and is encoded by a gene that maps to human chromosome 2q32.1 and mouse chromosome 2 C3. NAP125 expression is markedly reduced in Alzheimer disease (AD)-affected brains, suggesting a possible role in the disease. Function: Is part of lamellipodial complex that controls Rac-dependent actin remodeling.Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin膜相关的蛋白质HEM2抗体 filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Subcellular Location: Cell membrane. Cell projection Tissue Specificity: Expressed in all tissues examined except peripheral blood leukocytes, with highest expression in brain, heart, and skeletal muscle. Similarity: Belongs to the HEM-1/HEM-2 family. Database links: Entrez Gene: 3071 Human Entrez Gene: 1膜相关的蛋白质HEM2抗体05855 Mouse Entrez Gene: 315348 Rat Omim: 141180 Human SwissProt: P55160 Human Unigene: 182014 Human Unigene: 30805 Mouse Unigene: 149002 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
膜相关的蛋白质HEM2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 神经生物学 信号转导 干细胞 细胞凋亡 转录调节因子 细胞膜蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid