抑癌蛋白TCHP抗体
规格：1mg/1ml
英文名： TCHP
别名： TCHP; Trichoplein keratin filament-binding protein; Tumor suppressor protein.
分子量： 55kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TCHP
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse,
细胞定位：细胞浆 细胞膜
抑癌蛋白TCHP抗体产品介绍：background: A tumour suppressor protein which may act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. Function: Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells. Subunit: Interacts specifically with keratin proteins including, KRT5, KRT6A, KRT8, KRT14, KRT16 and KRT18. Subcellular Location: Cytoplasm, cytoskeleton. Cytoplasm. Cell membrane. Mitochondrion. Tissue Specificity: Expressed at high levels in normal抑癌蛋白TCHP抗体 urothelial and breast epithelial cells. Also expressed in the smooth muscle and endothelial cells. Reduced expression seen in advanced bladder and breast carcinomas (at protein level). Ubiquitous. Expressed at highest levels in the heart, skeletal muscle, kidney, 抑癌蛋白TCHP抗体liver and testis. Similarity: Belongs to the TCHP family. Database links: Entrez Gene: 84260 Human Omim: 612654 Human SwissProt: Q9BT92 Human Unigene: 410924 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
抑癌蛋白TCHP抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid