多聚**球蛋白受体抗体
规格：1mg/1ml
英文名： PIGR
别名： Hepatocellular carcinoma associated protein TB6; Phosphatidylinositol glycan, class R; PIgR; Poly Ig receptor; Polymeric immunoglobulin receptor; PIGR_HUMAN.
分子量： 81kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PIGR
交叉反应：Human, Mouse, Rat, Dog, Cow,
细胞定位：细胞膜 分泌型蛋白
多聚**球蛋白受体抗体产品介绍：background: This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.[provided by RefSeq, Sep 2009] Function: This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment. Subcellular Location: Cell membrane; Single-pass type I 多聚**球蛋白受体抗体membrane protein. Secretory component: Secreted. Post-translational modifications: N-glycosylation is not necessary for Ig binding. Similarity: Contains 5 Ig-like V-type (immunoglobulin-like) Gene ID: 5284 Database links: Entrez Gene: 5284 Human Entrez Gene: 18703 Mouse Omim: 173880 Human SwissProt: P01833 Human SwissProt: O70570 Mouse Unigene: 497589 Human Unigene: 276414 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 多聚**球蛋白受体多聚**球蛋白受体抗体（pIgR）属Ⅰ型跨膜糖蛋白，可与多聚**球蛋白A和多聚**球蛋白M特异性结合，通过穿胞转运，将它们从上皮细胞基底侧膜转运到顶膜，并*终分泌到外分泌液中去. 在此过程中，多聚**球蛋白受体的细胞外段被水解，释放出与多聚**球蛋白A或多聚**球蛋白M相结合的细胞外段（又称为分泌成分）. 分泌成分是sIgA分子的重要组成部分，直接参与sIgA的粘膜防御功能，而且在被动粘膜**中也有重要作用. 多聚**球蛋白受体通过介导细胞内多聚**球蛋白的转运，可以在粘膜的腔面阻止病原体粘附，在上皮细胞内中和病毒，也可以将固有层内的抗原分泌出去.
产多聚**球蛋白受体抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid