Notch信号通路Delta样配体4抗体
规格：1mg/1ml
英文名： Delta 4
别名： Delta 4; delta 4 precursor; Delta-4: Delta ligand 4; delta ligand 4 precursor; Delta like 4; Delta like 4 homolog; Delta like 4 protein; Delta like protein 4; Delta-like 4 (Drosophila); Delta-like pro
分子量： 72kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DLL4
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse,
细胞定位：细胞膜
Notch信号通路Delta样配体4抗体产品介绍：background: The LIN-12/Notch family of transmembrane receptors is believed to play a central role in development by regulating cell fate decisions. Notch proteins have been found to be overexpressed or rearranged in human tumors. Ligands for Notch include Jagged, Jagged-2 and Delta. While blocking the differentiation of progenitor cells into the B-cell lineage, Delta promotes the emergence of a population of cells with T cell/NK-cell characteristics. The protein is a membrane protein expressed in heart, pancreas, brain and muscle during gastrulation and early organogenesis and in ***** heart and lung. Delta-4 is a membrane protein that activates Notch-1 and Notch-4. It is expressed in a wide range of ***** and fetal tissues, especially in vascular endothelium. Function: Plays a role in the Notch信号通路Delta样配体4抗体Notch signaling pathway. Activates Notch-1 and Notch-4. Subunit: Binds to Notch-1 and Notch-4 (By similarity). Subcellular Location: Membrane; Single-pass type I membrane protein (Probable). Tissue Specificity: Expressed in vascular endothelium. Post-translational modifications: Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation. Similarity: Contains 1 DSL Notch信号通路Delta样配体4抗体domain. Contains 8 EGF-like domains. Gene ID: 54567 Database links: Entrez Gene: 54567 Human Entrez Gene: 54485 Mouse Omim: 605185 Human SwissProt: Q9NR61 Human SwissProt: Q9JI71 Mouse Unigene: 511076 Human Unigene: 143719 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Notch信号通路Delta样配体4抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 神经生物学 细胞周期蛋白 细胞膜受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid