脑组织表达X连锁蛋白1抗体
规格：1mg/1ml
英文名： Bex1
别名： BEX2; Brain expressed X linked 1; HBEX2; Protein BEX1; BEX1_HUMAN.
分子量： 15kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HBEX2/Be
交叉反应：Human, Mouse, Rat, Cow, Rabbit,
细胞定位：细胞核 细胞浆
脑组织表达X连锁蛋白1抗体产品介绍：background: The brain-expressed X-linked (Bex) family of proteins is expressed in the central nervous system, with highest levels detected in cerebellum, temporal lobe and pituitary tissues. Bex1 plays an important role in neuronal differentiation in response to nerve growth factor (NGF), as well as in cell cycle progression. Bex1 is a highly ubiquitinated protein and acts as a link between the cell cycle and neurotrophic factor signaling. Bex2 interacts with LMO2, thereby regulating the transcriptional activity of a DNA-binding complex. Bex1 and Bex 2 are widely expressed outside of the central nervous system with high expression in the liver. Bex1 and Bex2 shuttle between the cytoplasm and the nucleus. Though the role of Bex1 is largely unknown, it may function by coordinating internal cellular states with the ability of cells to respond to external signals. Function: ] Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and 脑组织表达X连锁蛋白1抗体neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity). Subunit: Interacts with neurotrophin receptor p75NTR/NGFR. Interacts with OMP (By similarity). Subcellular Location: Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm and the nucleus (By similarity). Tissue Specificity: Expressed in central nervous system, with high level in pituitary, cerebellum and temporal lobe. Expressed in lung, skeletal muscle, peripheral blood脑组织表达X连锁蛋白1抗体 leukocyte, stomach, lymph node, trachea and bone marrow. Highly expressed in acute myeloid leukemia. Post-translational modifications: Phosphorylated. Phosphorylation of Ser-102 protects it from the proteasome (By similarity). Ubiquitinated. Degraded by the proteasome (By similarity). Similarity: Belongs to the BEX family. Database links: UniProtKB/Swiss-Prot: Q9HBH7.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
脑组织表达X连锁蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 神经生物学 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid