干扰素诱导蛋白AIM2抗体
规格：1mg/1ml
英文名： AIM2
别名： Absent in melanoma 2; AIM 2; Aim2; AIM2_MOUSE; Interferon-inducible protein AIM2; OTTHUMP00000035296; PYHIN4.
分子量： 40kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from mouse AIM2.
交叉反应：Human, Mouse, Rat,
细胞定位：细胞核
干扰素诱导蛋白AIM2抗体产品介绍：background: AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. Function: Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8. Subunit: Self-associates; forms homooligomers in response to cytosolic dsDNA and the dsDNA seems to serve as oligomerization platform. Component of the AIM2 inflammasome complex. Interacts with干扰素诱导蛋白AIM2抗体 PYCARD. Interacts with IFI16 (By similarity). Interacts with EIF2AK2/PKR (By similarity). Subcellular Location: Nucleus (By similarity). Cytoplasm. Tissue Specificity: Expressed in spleen, small intestine, peripheral blood leukocytes, and testis. Similarity: Belongs to the HIN-200 family. Contains 1 DAPIN domain. Contains 1 HIN-200 domain. Gene ID: 383619 Database links: Entrez Gene: 9447 Human Entrez Gene: 383619 Mouse Entrez Gene: 304987 Rat Omim: 604578 Human SwissProt: O14862 Human SwissProt: Q91VJ1 Mouse Unigene: 281898 Human 干扰素诱导蛋白AIM2抗体Unigene: 733411 Human Unigene: 131453 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
干扰素诱导蛋白AIM2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:50-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 染色质和核信号 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid