核糖核酸酶6抗体
规格：1mg/1ml
英文名： Ribonuclease 6
别名： Ribonuclease T2; RNASE6PL; RP11 514O12.3; RNASET2; RNASE6PL; RNT2_HUMAN.
分子量： 27kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human RelB
交叉反应：Human, Mouse, Rat,
细胞定位：细胞浆 分泌型蛋白
核糖核酸酶6抗体产品介绍：background: This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement. There are 2 isoforms produced by alternative splicing. Subcellular Location: Secreted. Note=Subcellular fractionation of transfected ovarian cancer cells reveals full-length RNASET2 in the endoplasmic reticulum fraction and the 2 smaller RNASET2 proteolytic products in the lysosome fraction. Tissue Specificity: Ubiquitous. Higher expression levels observed in the temporal lobe and fetal brain. DISEASE: Defects in RNASET2 are the cause of leukoencephalopathy cystic without megalencephaly (LCWM) [MIM:612951]. An infantile-onset syndrome of cerebral leukoencephalopathy.核糖核酸酶6抗体 Affected newborns develop microcephaly and neurologic abnormalities including psychomotor impairment, seizures and sensorineural hearing impairment. The brain shows multifocal white matter lesions, anterior temporal lobe subcortical cysts, pericystic abnormal myelination, ventriculomegaly and intracranial calcifications. Similarity: Belongs to the RNase T2 family. Gene ID: 8635 Database links: Entrez Gene: 8635 Human Entrez Gene: 100037283 Mouse Entrez Gene: 68195 Mouse Entrez Gene: 292306 Rat Omim: 612944 Human SwissProt: O00584 Human SwissProt: 核糖核酸酶6抗体Q9CQ01 Mouse Unigene: 529989 Human Unigene: 181237 Mouse Unigene: 426736 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
核糖核酸酶6抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 信号转导 细胞凋亡 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid