Smad核转录共抑制因子抗体
规格：1mg/1ml
英文名： SnoN
别名： SKI like; Ski related oncogene; Ski related protein; SKIL; SnoA; SNO; SnoA; SnoI; SnoN; SKIL_HUMAN.
分子量： 77kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SnoN
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：
Smad核转录共抑制因子抗体产品介绍：background: SnoN may have a regulatory role in cell division or differentiation in response to extracellular signals. SnoN acts as a positive mediator of TGF beta induced transcription and cell cycle arrest in lung epithelial cells. The ability of SnoN to repress the growth inhibitory function of the Smad proteins is required for their transforming activity. Function: May have regulatory role in cell division or differentiation in response to extracellular signals. Subunit: Interacts with SMAD2, SMAD3 and RNF111. Smad核转录共抑制因子抗体Isoform 1 interacts with WWP1. Tissue Specificity: Isoform SNON and isoform SNOA are widely expressed. Highest expression is found in skeletal muscle, followed by placenta and lung. Lowest expression in heart, brain and pancreas. Isoform SNOI Smad核转录共抑制因子抗体expression is restricted to skeletal muscle. Similarity: Belongs to the SKI family. Database links: UniProtKB/Swiss-Prot: P12757.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Smad核转录共抑制因子(SnoN)是一种拮抗剂，可严格调控转化生长因子-β1/smad(TGF-β1/Smad)Smad核转录共抑制因子抗体信号的活性，从而保证在正常的生理条件下TGF-β1/smad信号输出的稳定性。
产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 染色质和核信号 信号转导 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid