血浆激肽释放酶重链抗体
规格：1mg/1ml
英文名： plasma kallikrein B1 heavy chain
别名： Plasma Kallikrein 1B; Plasma kallikrein B1; EC 3.4.21.34; Fletcher factor; Kallikrein 3 plasma (Fletcher factor); kallikrein B plasma; Kallikrein B plasma (Fletcher factor) 1; Kallikrein B, plasma 1;
分子量： 41kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human plasma k
交叉反应：Human, Mouse, Rat, Dog, Cow,
细胞定位：分泌型蛋白
血浆激肽释放酶重链抗体产品介绍：background: Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated血浆激肽释放酶重链抗体 partial thromboplastin time in patients. [provided by RefSeq, Jul 2008] Function: The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. Subunit: Forms a heterodimer with SERPINA5. The zymogen is activated by factor XIIa, which cleaves the molecule into a light chain, which contains the active site, and a heavy chain, which associates with HMW kininogen. These chains are linked by one or more disulfide bonds. Subcellular Location: Secreted. DISEASE: Prekallikrein deficiency 血浆激肽释放酶重链抗体(PKK deficiency) [MIM:612423]: This disorder is a blood coagulation defect. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the peptidase S1 family. Plasma kallikrein subfamily. Contains 4 apple domains. Contains 1 peptidase S1 domain. Gene ID: 3818 Database links: Entrez Gene: 3818 Human Entrez Gene: 25048 Rat Omim: 229000 Human SwissProt: P03952 Human SwissProt: P14272 Rat Unigene: 237642 Human Unigene: 9880 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
血浆激肽释放酶重链抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 激酶和磷酸酶 泛素
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid