去整合素样金属蛋白酶19抗体
规格：1mg/1ml
英文名： ADAM19
别名： A disintegrin and metalloproteinase domain 19 (meltrin beta); A disintegrin and metalloproteinase domain 19; ADAM 19; ADAM metallopeptidase domain 19; Disintegrin and metalloproteinase domain containi
分子量： 82kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ADAM19
交叉反应：Human, Mouse, Rat, Pig,
细胞定位：
去整合素样金属蛋白酶19抗体产品介绍：background: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has been demonstrated to be an active metalloproteinase, which may be involved in normal physiological processes such as cell migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. It is proposed to play a role in pathological processes, such as cancer, inflammatory diseases, renal diseases, and Alzheimer's disease. [provided by RefSeq, May 2013]. Function: Participates in the proteolytic processing of beta-type neuregulin isoforms 去整合素样金属蛋白酶19抗体which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity). Subunit: Interacts with SH3PXD2A. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Expressed in many normal organ tissues and several cancer cell lines. Post-translational modifications: The precursor is cleaved by a furin endopeptidase (By similarity). Similarity: Contains 1 disintegrin domain.去整合素样金属蛋白酶19抗体 Contains 1 EGF-like domain. Contains 1 peptidase M12B domain. Database links: Entrez Gene: 8728 Human Entrez Gene: 11492 Mouse Entrez Gene: 303068 Rat Omim: 603640 Human SwissProt: Q9H013 Human SwissProt: O35674 Mouse SwissProt: Q14BL7 Mouse SwissProt: Q80UF6 Mouse Unigene: 89940 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 细胞外基质蛋白
去整合素样金属蛋白酶19抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 信号转导 细胞骨架 细胞外基质 泛素
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid