去整合素样金属蛋白酶18抗体
规格：1mg/1ml
英文名： ADAM18
别名： A disintegrin and metalloproteinase domain 18; ADAM 18; ADA18_HUMAN; ADAM 27; ADAM metallopeptidase domain 18; ADAM27; MGC41836; MGC88272; TMDC3; tMDCIII; Transmembrane metalloproteinase like, disinte
分子量： 62kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ADAM18
交叉反应：Human, Dog,
细胞定位：
去整合素样金属蛋白酶18抗体产品介绍：background: ADAM18 was first described as tMDC III (testis-specific Metalloproteinase-like disintergin-like cysteine-rich protein-III). ADAM18 is a member of the ADAMs family (A Disintegrin And Metalloproteinase), but does not contain the canonical HExxHxxxxH zinc-binding metalloproteinase catalytic site. The domain structure of the fill-length ADAM18 includes a signal sequence, propeptide domain, metalloproteinase-like domain, disintegrin-like domain, cys-rich domain, EGF-like domain, a short spacer region, then the transmembrane domain and a cytoplasmic domain. Like many of the reproductive-specific ADAMS, ADAM18 plays a nonenzymatic role, or (as is the case for ADAMs 1 & 2 (fertilin alpha and beta)), the protein acts in concert with a proteolytically active ADAM to process proteins. Little is known about interactions between ADAM18 and other ADAMs. To date, 4 different sequences for human ADAM18 are published; 739, 715, 去整合素样金属蛋白酶18抗体182 and 153 amino acids in length. Function: Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Expressed specifically in testis. Post-translational modifications: The prodomain and the metalloprotease-like domain are cleaved during the epididymal maturation of the spermatozoa. Similarity: Contains 1 disintegrin domain. Contains 1 EGF-like domain. Contains 1 peptidase M12B domain. 去整合素样金属蛋白酶18抗体Database links: Entrez Gene: 8728 Human Entrez Gene: 11492 Mouse Entrez Gene: 303068 Rat Entrez Gene: 510907 Cow Omim: 603640 Human SwissProt: Q9H013 Human SwissProt: O35674 Mouse SwissProt: Q14BL7 Mouse SwissProt: Q80UF6 Mouse Unigene: 89940 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 细胞外基质蛋白
去整合素样金属蛋白酶18抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 信号转导 细胞骨架 细胞外基质 泛素
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid