IGFBP2结合蛋白/迁移和侵润抑制蛋白抗体
规格：1mg/1ml
英文名： MIIP
别名： FLJ12438; FLJ38609; IGFBP 2 binding protein; IGFBP2 binding protein; IIP45; Invasion inhibitory protein 45; Migration and invasion inhibitory protein; RP5 1077B9.4.
分子量： 43kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MIIP
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Rabbit,
细胞定位：
IGFBP2结合蛋白/迁移和侵润抑制蛋白抗体产品介绍：background: MIIP has 3 SEG (segments of low compositional complexity) domains, an RGD motif, and several potential phosphorylation sites. The C-terminal region of IGFBP2 interacts with a central 44-amino acid sequence of MIIP. MIIP inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. It exhibits opposing effects to IGFBP2 on cell invasion. There are 2 named isoforms due to alternative splicing. Isoform 1 is expressed in brain but underexpressed in glioma tissues, at protein level. Isoform 2 is not detected in normal organs, but is expressed in gliomas with increasing levels with glioma progression. On the contrary, at protein level, isoform 2 is not detected in gliomas, suggesting that this isoform is unstable in gliomaIGFBP2结合蛋白/迁移和侵润抑制蛋白抗体 cells. Isoform 2 is degraded by the ubiquitin-proteasome pathway. Function: Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion. Subunit: Interacts with IGFBP2. Tissue Specificity: Ubiquitous. Isoform 1 is expressed in brain but underexpressed in glioma tissues, at protein level. Isoform 2 is not detected in normal organs, but is expressed in gliomas with increasing levels with glioma progression. On the contrary, at protein level,IGFBP2结合蛋白/迁移和侵润抑制蛋白抗体 isoform 2 is not detected in gliomas, suggesting that this isoform is unstable in glioma cells. Post-translational modifications: Isoform 2 is degraded by the ubiquitin-proteasome pathway. Database links: UniProtKB/Swiss-Prot: Q5JXC2.3 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
IGFBP2结合蛋白/迁移和侵润抑制蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 神经生物学 细胞粘附分子 细胞骨架 细胞膜蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid