脑发育调节蛋白抗体
规格：1mg/1ml
英文名： Drebrin
别名： D0S117E; DBN 1; DBN1; Developmentally regulated brain protein; Developmentally-regulated brain protein; DKFZp434D064; DREB_HUMAN; Drebrin 1; Drebrin; Drebrin E; Drebrin1; DrebrinE.
分子量： 71kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Drebrin
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：细胞浆
脑发育调节蛋白抗体产品介绍：background: Drebrin is a major neuronal F-actin binding protein involved in the control of actin dynamics and neuronal morphogenesis. Three major isoforms of drebrin, resulting from alternative splicing of a single gene, have been identified in the brain: the embryonic isoforms designated E1 and E2 and the ***** or A isoform (95-120 kDa). An additional truncated form of drebrin A, s-drebrin/A2 (42 kDa), is specifically expressed in the ***** brain, but not in non-neuronal tissues. Drebrin is also widely expressed in a variety of cells including epithelial, endothelial, and smooth muscle cells and is associated at cell-cell adhering junction sites. Drebrin is thought to play a central role in the formation of axons and dendrites during neuronal development and in neuronal plasticity in the ***** brain. The expression of each drebrin isoform is regulated throughout distinct phases in neuronal development. The earliest embryonic form E1, is thought to function in migration, while the E2 isoform, which replaces E1 during embryogenesis, is believed to play a role in migration as well as formation of axons and dendrites. Drebrin E2 is present at low levels in the ***** brain. The drebrin A isoform, which is only present in mature neurons, is assumed to be involved in synaptic plasticity. 脑发育调节蛋白抗体Drebrin E2 and A isoforms are targeted to different regions of actin localization. In neurons, the E2 isoform localizes to the submembrane region, while the A isoform is specifically located and evenly distributed throughout the post-synaptic dendritic spine. Function: Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites, respectively. Subunit: Contains 1 ADF-H domain. Subcellular Location: Cytoplasm. Tissue Specificity: Brain neurons. Also found in the heart, placenta, skeletal muscle, kidney and pancreas. Similarity: 脑发育调节蛋白抗体Contains 1 ADF-H domain. Database links: UniProtKB/Swiss-Prot: Q16643.4 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产脑发育调节蛋白抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 神经生物学 信号转导 细胞粘附分子 结合蛋白 细胞类型标志物 血管内皮细胞 细胞骨架 细胞外基质
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid