造血干细胞抗原CD133相关蛋白抗体
规格：1mg/1ml
英文名： Prominin 2
别名： hPROML2; PROM 2; PROM2; Prominin like protein 2; Prominin related protein; PROML2; PROM2_HUMAN.
分子量： 89kD
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Prominin
交叉反应：Human, Mouse, Rat, Dog, Pig,
细胞定位：细胞膜
产造血干细胞抗原CD133相关蛋白抗体品介绍：background: Prominin 2 is a 112 kDa glycoporotein structurally related to Prominin 1 (CD133) although amino acid similarity is not more than 30%, but their genomic organization is strikingly similar. Like Prominin 1, the prominin 2 exhibit similar membrane topology with 5 trans-membrane domains and two large glycosylated extracellular domains. Similar to Prominin1 localization, the Prominin 2 is also associated with membrane protrusions of the epithelial cells from ***** kidney, and all along the digestive track and other epithelial tissues. Prominin 2 expression is down-regulated in aggressive prostate cancer cell lines and transient transfection of PROML2 expression vectors has been shown to induce apoptosis in cultured prostate cancer cells, suggesting a tumor suppressive role for Prominin 2. Prominin 2 expression is likely to be involved in growth suppression in the prostate, and down-regulation of Prominin 2 may disrupt normal prostatic homeostasis and lead to uncontrolled prostatic growth. Subunit: Binds cholesterol (By similarity). Subcellular Location: Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Cell projection, microvillus membrane; Multi-pass membrane protein.造血干细胞抗原CD133相关蛋白抗体Cell projection, cilium membrane; Multi-pass membrane protein. Tissue Specificity: Present in saliva within small membrane particles (at protein level). Expressed in kidney, prostate, trachea, esophagus, salivary gland, thyroid gland, mammary gland adrenal gland, placenta, stomach, spinal cord and liver. In submucosal tumor, expressed in spindle-shaped or stellate stromal cells. Expressed in prostate cancer cell lines. Post-translational modifications: Glycosylated (By similarity). Similarity: Belongs to the prominin family. Gene ID: 150696 Database造血干细胞抗原CD133相关蛋白抗体 links: Entrez Gene: 150696 Human Entrez Gene: 192212 Mouse Entrez Gene: 192211 Rat SwissProt: Q8N271 Human SwissProt: Q3UUY6 Mouse SwissProt: Q8CJ52 Rat Unigene: 469313 Human Unigene: 34171 Mouse Unigene: 82155 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
造血干细胞抗原CD133相关蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 染色质和核信号 信号转导 细胞凋亡 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid