BCL2分子伴侣调节蛋白5抗体
规格：1mg/1ml
英文名： BAG5
别名： BAG family molecular chaperone regulator 5; BAG 5; BAG-5; BCL2 associated athanogene 5; KIAA0873; BAG5_HUMAN.
分子量： 51kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human BAG5
交叉反应：Human, Mouse, Rat, Chicken, Dog,
细胞定位：细胞浆
BCL2分子伴侣调节蛋白5抗体产品介绍：background: BAG5 is a member of the BAG1 related protein family. BAG1 is an anti apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL 2, Raf protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. A BAG domain near the C terminus, may bind and inhibit the chaperone activity of Hsc70/Hsp70. It has been hypothesized that the BAG5 protein will induce the death of nigral neurons through its predicted interaction with hsp70, which will cause increased protein aggregation and cell death by disinhibition of hsp70’s anti apoptotic function. It is believed that BAG5 will play an important role in the mechanisms of neuronal death. BAG5 may also be of interest due to its possible role as a modulator of the hsp70/hsp40 chaperone axis or its possible interaction and coordination of localization/modulation of other BAG containingBCL2分子伴侣调节蛋白5抗体 proteins via BAG-BAG heterodimerization. Function: Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2 (By similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding. Subunit: Binds to the ATPase domain of HSP/HSC70 chaperones. Binds PARK2 (By similarity). Similarity: Contains 5 BAG domains. Database links: Entrez Gene: 423482 Chicken Entrez Gene: 522854 Cow Entrez Gene: 480444 Dog Entrez Gene: 101147801 Gorilla Entrez BCL2分子伴侣调节蛋白5抗体Gene: 100146239 Horse Entrez Gene: 9529 Human Entrez Gene: 70369 Mouse Entrez Gene: 366734 Rat Omim: 603885 Human SwissProt: Q2TA08 Cow SwissProt: Q9UL15 Human SwissProt: Q8CI32 Mouse SwissProt: Q5QJC9 Rat Unigene: 5443 Human Unigene: 44239 Mouse Unigene: 76368 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
BCL2分子伴侣调节蛋白5抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 细胞凋亡
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid