轴突导向受体抗体
规格：1mg/1ml
英文名： Robo
别名： Axon guidance receptor; Deleted in U twenty twenty; DUTT 1; DUTT1; FLJ21882; H Robo 1; H-Robo-1; hRobo 1; Robo 1; Robo1; ROBO1_HUMAN; Roundabout 1; Roundabout axon guidance receptor homolog 1; Roundab
分子量： 181kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Robo.
交叉反应：Human, Mouse, Rat,
细胞定位：细胞膜
轴突导向受体抗体产品介绍：background: Specialized cells at the midline, which separates the left and right halves of the CNS, have a number of roles in directing growth cone behavior (1). In the vertebrate spinal cord, the insect ventral nerve cord and in C. elegans, midline cells produce guidance cues such as nectins and slit, which act as attractants and repellents, respectively (1). These cells may act as gatekeepers to prevent axons from crossing the midline and to induce a switch in growth cone responsiveness to guidance cues beyond the gateway (1). One such gatekeeper, Robo, is an axon guidance receptor that defines a novel subfamily of Ig superfamily proteins that are conserved from fruit flies to mammals (2,3). Robo acts as a receptor for the repellent Slit and functions in a cell-autonomous fashion (1-3). Non-crossing axons express high levels of Robo, whereas crossing axons express low levels of Robo before reaching the midline and high levels after they cross (1). Robo1 and Robo2 are two human homologs of the Drosophila protein Roundabout (2-4). Robo1 is also homologous to the C. elegans gene sax3, whereas Robo2 is轴突导向受体抗体 homologous to the zebrafish gene astray (5,6). Function: Receptor for SLIT1 and SLIT2 which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex. May be required for lung development. Subcellular Location: Membrane. Tissue Specificity: Widely expressed, with exception of kidney. Post-translational modifications: Ubiquitinated. May be deubiquitinated by USP33. Similarity: Belongs to the immunoglobulin superfamily. 轴突导向受体抗体ROBO family. Contains 3 fibronectin type-III domains. Contains 5 Ig-like C2-type (immunoglobulin-like) domains. Database links: Entrez Gene: 6091 Human Entrez Gene: 19876 Mouse Omim: 602430 Human SwissProt: Q9Y6N7 Human SwissProt: O89026 Mouse Unigene: 13640 Human Unigene: 310772 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
轴突导向受体抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 神经生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid