结肠和肝肿瘤高表达蛋白抗体
规格：1mg/1ml
英文名： CKAP5
别名： Ch TOG protein; chTOG; CHTOG protein; CKAP5_HUMAN; CKAP 5; CKAP5; CKAP5 protein; Colonic and hepatic tumor over expressed; Colonic and hepatic tumor over expressed protein; Colonic and hepatic tumor o
分子量： 225kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CKAP5/ch
交叉反应：Human, Mouse, Rat, Dog, Horse, Rabbit,
细胞定位：
结肠和肝肿瘤高表达蛋白抗体产品介绍：background: CKAP5 is a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding different isoforms have been identified.结肠和肝肿瘤高表达蛋白抗体 Function: Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. Subunit: Interacts with TACC1. Interacts with SLAIN2. Subcellular Location: Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Detected on centrosomes during interphase. Detected on spindle poles and microtubules during mitosis. Tissue Specificity: Overexpressed in hepatomas and colonic tumors.结肠和肝肿瘤高表达蛋白抗体 Also expressed in skeletal muscle, brain, heart, placenta, lung, liver, kidney and pancreas. Similarity: Belongs to the TOG/XMAP215 family. Contains 10 HEAT repeats. Database links: UniProtKB/Swiss-Prot: Q14008.3 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产结肠和肝肿瘤高表达蛋白抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 细胞周期蛋白 细胞分化 细胞类型标志物 细胞骨架
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid