卵巢癌相关基因1抗体
规格：1mg/1ml
英文名： OVCA1
别名： Candidate tumor suppressor in ovarian cancer 1; Diphthamide biosynthesis protein 1; Diphthamide biosynthesis protein 2 homolog like 1; Diphthamide biosynthesis protein 2 like; Diptheria toxin resistan
分子量： 49kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human OVCA1
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Rabbit,
细胞定位：
卵巢癌相关基因1抗体产品介绍：background: OVCA1 is required for the first step in the synthesis of diphthamide, a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. OVCA1 is one of several enzymes involved in synthesis of diphthamide in EEF2. Function: Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2. When overexpressed, suppresses colony 卵巢癌相关基因1抗体formation ability and growth rate of ovarian cancer cells. Acts also as a tumor suppressor in lung and breast cancers (By similarity). Plays a role in embryonic growth, organogenesis and postnatal survival (By similarity). Subunit: Interacts with DPH2 (By similarity). Interacts with RBM8A. Subcellular Location: Nucleus. Cytoplasm. Note=Punctate, primarily perinuclear localization. Tissue Specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, mammary gland, colon, small intestine, testis and ovary卵巢癌相关基因1抗体. Reduced expression in primary breast and ovarian tumors. Similarity: Belongs to the DPH1/DPH2 family. DPH1 subfamily. Database links: UniProtKB/Swiss-Prot: Q9BZG8.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
卵巢癌相关基因1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 细胞周期蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid