成纤维细胞生长因子受体1原癌基因伴侣蛋白抗体
规格：1mg/1ml
英文名： FGFR1OP
别名： FGFR1OP; Fibroblast growth factor receptor 1 oncogene partner; FOP; FR1OP_HUMAN.
分子量： 43kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human FGFR1OP
交叉反应：Human, Mouse, Rat, Horse,
细胞定位：细胞浆
成纤维细胞生长因子受体1原癌基因伴侣蛋白抗体产品介绍：background: FGFR1 Oncogene Partner is required for anchoring microtubules to the centrosomes. Ubiquitous; highly expressed in heart, liver, muscle, kidney, intestine, colon, adrenal gland, prostate, testis, and pancreas. A chromosomal aberration involving FGFR1OP may be a cause of stem cell myeloproliferative disorder (MPD). There are three named isoforms. Function: Required for anchoring microtubules to the centrosomes. Subunit: Homodimer. Part of a ternary complex that contains CEP350, FGFR1OP and MAPRE1. Interacts directly with CEP350 and MAPRE1. Subcellular Location: Cytoplasm, cytoskeleton, centrosome. Note=Associated with gamma-tubulin. Tissue Specificity: Ubiquitous. Highly expressed in heart, liver, muscle, kidney, intestine, colon, adrenal gland, 成纤维细胞生长因子受体1原癌基因伴侣蛋白抗体prostate, testis, and pancreas. DISEASE: Note=A chromosomal aberration involving FGFR1OP may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(6;8)(q27;p11) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion proteins FGFR1OP-FGFR1 or FGFR1-FGFR1OP may exhibit constitutive kinase activity and be responsible for the transforming activity. Similarity: Belongs to the FGFR1OP成纤维细胞生长因子受体1原癌基因伴侣蛋白抗体 family. Contains 1 LisH domain. Database links: UniProtKB/Swiss-Prot: O95684.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. FGFR1OP蛋白*初是在引起干细胞骨髓增生病的癌蛋白中作为FGFR1的融合伴侣被发现的，目前研究认为，FGFR1OP蛋白在很多组织细胞中都有不同的存在，尤其是以脑, 心，肝，肌肉，肾，小肠，结肠，肾上腺，前列腺，睾丸和胰腺中高表达。
成纤维细胞生长因子受体1原癌基因伴侣蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 神经生物学 生长因子和**
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid