磷酸化信号**细胞活化分子CD150抗体
规格：1mg/1ml
英文名： phospho-SLAMF1 (Tyr281)
别名： SLAMF1(phospho Y281); CD150 antigen; Cdw150; Estm51; Ipo 3; Ipo3; MGC151472; MGC151476; Signaling lymphocytic activation molecule; Signaling lymphocytic activation molecule family member 1; Signaling
分子量： 35kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated Synthesised phosphopeptide derived from human
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,
细胞定位：
磷酸化信号**细胞活化分子CD150抗体产品介绍：background: SLAM, a novel glycoprotein of 37kDa, designated SLAM (Signaling Lymphocyte Activation Molecule) or CDw150, belongs to the immunoglobulin gene superfamily and is involved in T cell stimulation. SLAM is constitutively expressed on peripheral blood memory T cells, T cell clones, immature thymocytes, and a proportion of B cells, and is rapidly induced on naive T cells after activation. Activated B cells express the membrane bound form of SLAM and the soluble and cytoplasmic isoforms of SLAM, and the expression levels of membrane bound SLAM on B cells are rapidly regulated after activation in vitro. It is suggested that signalling through homophilic SLAM-SLAM binding during B to B and B to T cell interactions enhances the expansion and differentiation of activated B cells. Reports suggest that the extracellular domain of CD150 is the receptor for the measles virus and acts as a co-activator on T cells and B cells. Function: High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from 磷酸化信号**细胞活化分子CD150抗体those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates. Subunit: nteracts (via cytoplasmic domain) with SH2D1A, and withPTPN11. Interacts with INPP5D/SHIP1. Binds to Measles virus Hprotein and acts as a receptor for this virus. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Note=Present on the surface of B-cells and T-cells. Tissue Specificity: Constitutively expressed on peripheral blood memory T-cells, T-cell clones, immature thymocytes and a proportion of B-cells, and is rapidly induced on naive T-cells after activation. Post-translational modifications: Phosphorylated by FYN. Similarity: Contains 1 Ig-like C2-type 磷酸化信号**细胞活化分子CD150抗体(immunoglobulin-like) domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain. Gene ID: 6504 Database links: Entrez Gene: 6504 Human Entrez Gene: 27218 Mouse Entrez Gene: 498286 Rat Omim: 603492 Human SwissProt: Q13291 Human SwissProt: Q9QUM4 Mouse Unigene: 523660 Human Unigene: 103648 Mouse Unigene: 215687 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. CD150（SLAM）为磷酸化信号**细胞活化分子CD150抗体70kD的表面糖蛋白属于**球蛋白基因超家族。SLAM有直接诱导CD4阳性T细胞克隆与活化前T细胞的作用。CD150抗原还可以增强抗原特异性增生与通过T细胞携带的CD4抗原产生细胞因子，特别是对干扰素-γ具有极强的上调节作用。SLAM与自身配体具有极高亲和性，由SLAM同源亲和细胞间的相互作用能够刺激T**细胞产生自身因子。CD150抗原还是风疹病毒细胞受体并且通过白介素10下调节。
产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 信号转导 t-**细胞 b-**细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid