磷酸化沉默调节相关蛋白6抗体
规格：1mg/1ml
英文名： phospho-SIRT6(Ser338)
别名： SIRT6(phospho S338); 2810449N18Rik; AI043036; Mono ADP ribosyltransferase sirtuin 6; NAD-dependent deacetylase sirtuin-6; NAD-dependent protein deacetylase sirtuin-6; SIR2 like 6; SIR2 like protein 6;
分子量： 39kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthesised phosphopeptide derived from human
交叉反应：Human,
细胞定位：细胞核
磷酸化沉默调节相关蛋白6抗体产品介绍：background: NAD-dependent protein deacetylase. Has deacetylase activity towards 'Lys-9' and 'Lys-56' of histone H3. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates 'Lys-9' of histone H3 at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. Regulates the production of TNF protein. Function: NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for 磷酸化沉默调节相关蛋白6抗体genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate. Subunit: Interacts with RELA. Interacts with RBBP8; the interaction deacetylates RBBP8. Subcellular Location: Nucleus, nucleoplasm. Similarity: Belongs to the sirtuin family. Class IV subfamily. Contains 1 deacetylase sirtuin-type domain. 磷酸化沉默调节相关蛋白6抗体Database links: UniProtKB/Swiss-Prot: Q8N6T7.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. SIRT6是一种酶，能够从组蛋白的一个特定位点上移走称之为乙酰基组的化学物质。组蛋白对调控基因表达非常重要，而从组蛋白中移除乙酰基组就会“关闭”某些基因表达。 SIRT6蛋白与NF-kappaB（NF-kB）一同，可以调节凋亡、炎症和新陈代谢相关基因的作用。当减少SIRT6时，NF-kappaB变得过度活跃，开启同衰老相关的基因。
磷酸化沉默调节相关蛋白6抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 **学 染色质和核信号 信号转导 细胞凋亡 新陈代谢 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid