磷酸化高迁移率核小体结合蛋白1
规格：1mg/1ml
英文名： phospho-HMG14(Ser20+Ser24)
别名： HMG14 (phospho S20 + S24); High mobility group (nonhistone chromosomal) protein 14; High mobility group nucleosome binding 1; High mobility group nucleosome binding domain containing protein 1; High m
分子量： 11kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated Synthesised phosphopeptide derived from mouse
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit,
细胞定位：细胞核 细胞浆
磷酸化高迁移率核小体结合蛋白1产品介绍：background: Chromosomal protein HMG14 binds to the inner side of the nucleosomal DNA, thus altering the interaction between the DNA and the histone octamer and is involved in the process that maintains transcribable genes in an appropriate chromatin conformation. HMG14 has been implicated as a contributing factor in the etiology of Down syndrome. Function: Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in an unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2. Subcellular Location: Nucleus. Cytoplasm. Cytoplasmic enrichment upon phosphorylation. The RNA edited version localizes to the nucleus. Post-translational modifications: Phosphorylation on Ser-21 and Ser-25 weakens binding to nucleosomes and increases the rate of H3 phosphorylation (By similarity). Phosphorylation favors cytoplasmic localization. Similarity: Belongs to the HMGN family. Gene ID: 磷酸化高迁移率核小体结合蛋白115312 Database links: Entrez Gene: 614915 Cow Entrez Gene: 3150 Human Entrez Gene: 100044391 Mouse Entrez Gene: 15312 Mouse Omim: 163920 Human SwissProt: P02316 Cow SwissProt: P05114 Human SwissProt: P18608 Mouse Unigene: 87121 Cow Unigene: 356285 Human Unigene: 702472 Human Unigene: 2756 Mouse Important Note: This product as supplied is intended for research磷酸化高迁移率核小体结合蛋白1 use only, not for use in human, therapeutic or diagnostic applications. HMGN1是一个核仁结合蛋白, 属于核小体结合高速迁移蛋白家族(A family of High Mobility Group Proteins that bind to Nucleosomesn, HMGN)含量蛋白较高,能稳定染色质的二级结构, 修复紫外线诱导的染色质DNA损伤. HMGN1的缺失可导致细胞增殖和生长发生紊乱, 通过打乱细胞的生长控制机制使一些致癌因素更为敏感并发生恶性转化. 研究表明, HMGN1在细胞核内是动态表达的,与细胞的新陈代谢有关. HMGN1蛋白和核仁的相互作用可改变染色质的结构, 并且能调节各种与DNA相关的包括转录的细胞核作用.
磷酸化高迁移率核小体结合蛋白1产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 染色质和核信号 神经生物学 信号转导 细胞周期蛋白 结合蛋白 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid