磷酸化RhoA蛋白抗体
规格：1mg/1ml
英文名： Phospho-RhoA(Ser188)
别名： RHOA(phospho S188); RhoA (phospho S188); RhoA protein; Aplysia ras related homolog 12; ARH 12; ARH12; ARHA; H 12; Oncogene RHO H12; Ras homolog gene family member A; RHO 12; Rho A; RHO H12; RHO12; RHO
分子量： 21kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated Synthesised phosphopeptide derived from human
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Sheep,
细胞定位：细胞浆 细胞膜
磷酸化RhoA蛋白抗体产品介绍：background: This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. Subunit: nteracts with RGNEF. Binds PRKCL1, ROCK1 and ROCK2. Interacts with ARHGEF2, ARHGEF3, NET1 and RTKN. Interacts with PLCE1 and AKAP13. Interacts (in the constitutively activated, GTP-bound form) with DGKQ. Interacts with human respiratory syncytial virus (HRSV)磷酸化RhoA蛋白抗体protein F; this interaction facilitates virus-induced syncytium formation. Interacts with GNB2L1/RACK1; enhances RHOA activation. Interacts with PKP4; the interaction is detected at the midbody. Interacts (GTP-bound form preferentially) with PKN2; the interaction stimulates autophosphorylation and phosphorylation of PKN2. Similarity: Belongs to the small GTPase superfamily. Rho family. Database links: Entrez Gene: 磷酸化RhoA蛋白抗体387 Human Entrez Gene: 11848 Mouse Entrez Gene: 117273 Rat Omim: 165390 Human SwissProt: P61586 Human SwissProt: Q9QUI0 Mouse SwissProt: P61589 Rat Unigene: 247077 Human Unigene: 757 Mouse Unigene: 107401 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. RhoA蛋白主要分布在细胞质和细胞膜,RhoA蛋白家族是控制细胞骨架蛋白组合、调节基因表达等细胞活动过程中的关键信号转导成分。通常,RhoA通过激活其下游的Rho 连接激酶(Rho associated kinase,ROK)而起作用。在调节细胞骨架组建的过程中,RhoA与其作用对象均在胞质内。
磷酸化RhoA蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 信号转导 细胞凋亡 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid