磷酸化活化转录因子4抗体
规格：1mg/1ml
英文名： phospho-ATF4 (Ser245)
别名： ATF4 (phospho S245); ATF4(Phospho-Ser245); Cyclic AMP response element binding protein 2; DNA binding protein TAXREB67; Activating Transcription Factor 4; ATF 4; ATF4 protein; CREB 2; CREB2; CREB-2; C
分子量： 38kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated Synthesised phosphopeptide derived from human
交叉反应：Human,
细胞定位：细胞核 细胞浆 细胞膜
磷酸化活化转录因子4抗体产品介绍：background: ATF4 is a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain (referenced from Entrez gene). Function: Transcriptional activator. Binds the cAMP 磷酸化活化转录因子4抗体response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Subcellular Location: Cytoplasm. Cell membrane. Nucleus. Colocalizes with GABBR1 in hippocampal neuron dendritic membranes. Similarity: Belongs to the bZIP family. Contains 1 bZIP domain.磷酸化活化转录因子4抗体 Database links: Entrez Gene: 468 Human Entrez Gene: 11911 Mouse Entrez Gene: 79255 Rat NCBI: 33469976 Human Omim: 604064 Human SwissProt: P18848 Human SwissProt: Q96AQ3 Human SwissProt: Q06507 Mouse SwissProt: Q5U4B2 Mouse SwissProt: Q8CF69 Mouse SwissProt: Q9ES19 Rat Unigene: 496487 Human Unigene: 641 Mouse Unigene: 2423 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
磷酸化活化转录因子4抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 信号转导 细胞凋亡 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid