氯离子通道蛋白27抗体
规格：1mg/1ml
英文名： CLIC1
别名： hRNCC; Nuclear chloride ion channel 27; p64CLCP; Chloride channel ABP; Chloride intracellular channel 1; Chloride intracellular channel protein 1; CLIC 1; CLIC1; CLIC1_HUMAN; G6 antibody hRNCC; NCC 27
分子量： 26kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NCC27
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Rabbit,
细胞定位：细胞核 细胞浆 细胞膜
氯离子通道蛋白27抗体产品介绍：background: Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. [provided by RefSeq, Jul 2008] Function: Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle. Subunit: Monomer. Homodimer (in vitro). Interacts with TRAPPC2. Dimerization requires a conformation change that leads to the exposure of a large hydrophobic surface. In vivo, this may lead to membrane insertion. Interacts with AKAP9. Subcellular Location: Nucleus. Nucleus membrane; Single-pass membrane protein (Probable). Cytoplasm. Cell membrane; Single-pass membrane protein (Probable). 氯离子通道蛋白27抗体Tissue Specificity: Expression is prominent in heart, placenta, liver, kidney and pancreas. Post-translational modifications: Hydrogen peroxide treatment causes a conformation change, leading to dimerization and formation of an intramolecular disulfide bond between Cys-24 and Cys-59. Similarity: Belongs to the chloride channel CLIC family. Contains 1 GST C-terminal domain. Database links: Entrez Gene: 氯离子通道蛋白27抗体1192 Human Entrez Gene: 515646 Cow Entrez Gene: 114584 Mouse Entrez Gene: 594847 Pig Entrez Gene: 406864 Rat Omim: 602872 Human SwissProt: Q5E9B7 Cow SwissProt: O00299 Human SwissProt: Q9Z1Q5 Mouse SwissProt: Q6MG61 Rat Unigene: 414565 Human Unigene: 29524 Mouse Unigene: 203139 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产氯离子通道蛋白27抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 转录调节因子 通道蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid