造血干细胞特异性蛋白抗体
规格：1mg/1ml
英文名： HCLS1
别名： Cortactin like; CTTNL; HCLS 1; HCLS 1 protein; Hcls1; HCLS1 protein; HCLS1_HUMAN; Hematopoietic cell specific Lyn substrate 1; Hematopoietic cell-specific LYN substrate 1; Hematopoietic lineage cell s
分子量： 53kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HCLS1
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Rabbit,
细胞定位：细胞浆 细胞膜
造血干细胞特异性蛋白抗体产品介绍：background: Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression. Function: Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression. Subunit: Associates with the SH2 and SH3 domains of LCK. Binding to he LCK SH3 domain occurs constitutively, while binding to the LCK SH2 domain occurs only upon TCR stimulation. A similar binding pattern was observed with LYN, but not with FYN in which the FYN SH2 region associates upon TCR stimulation but the FYN SH3 region does not associate regardless of TCR stimulation. Directly associates with HAX1, through binding to its C-terminal region. Interacts with HS1BP3. Interacts with FES/FPS造血干细胞特异性蛋白抗体. Interacts (via SH2 domain) with FGR. Forms a multiprotein complex with LYN and ANKRD54. Subcellular Location: Membrane; Peripheral membrane protein. Cytoplasm. Mitochondrion (Probable). Tissue Specificity: Expressed only in tissues and cells of hematopoietic origin. Post-translational modifications: Phosphorylated by FES (By similarity). Phosphorylated by LYN, FYN and FGR after cross-linking of surface IgM on B-cells. Phosphorylation by LYN, FYN and FGR requires prior phosphorylation by SYK or FES. Similarity: Contains 4 cortactin repeats. 造血干细胞特异性蛋白抗体Contains 1 SH3 domain. Database links: Entrez Gene: 3059 Human Entrez Gene: 15163 Mouse Omim: 601306 Human SwissProt: P14317 Human SwissProt: P49710 Mouse Unigene: 14601 Human Unigene: 4091 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
造血干细胞特异性蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid