胰岛素样生长因子结合蛋白7抗体
规格：1mg/1ml
英文名： IGFBP7
别名： AGM; Angiomodulin; FSTL2; IBP-7; IBP7; IBP7_HUMAN; IGF binding protein 7; IGF-binding protein 7; IGFBP rP1; IGFBP-7; IGFBP-rP1; IGFBP7; IGFBPRP1; Insulin like growth factor binding protein 7; Insulin-
分子量： 26kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human IGFBP7 (
交叉反应：Human, Mouse, Rat, Dog, Cow, Sheep,
细胞定位：分泌型蛋白
胰岛素样生长因子结合蛋白7抗体产品介绍：background: IGF-BPs form high affinity complexes with both IGF-I and IGF-II and act to control of the distribution, function and activity of IGFs in various cell tissues and body fluids. There are seven named IGF-BPs. IGFBP7 plays a role in skeletal myogenesis by binding to IGF in a manner that inhibits IGF induced differentiation of skeletal myoblasts, without affecting IGF induced proliferation. Additionally, IGFBP7 suppresses growth and colony formation of prostate and breast cancer cell lines through an IGF independent mechanism, which causes a delay in the G1 phase of the cell cycle, and increased apoptosis. IGFBP7 is expressed in a wide range of normal human tissues and it usually shows reduced expression in cancer cell lines of prostate, breast, colon, and lung origin. Function: Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. Subunit: May interact with胰岛素样生长因子结合蛋白7抗体 VPS24/CHMP3; the relevance of such interaction however remains unclear. Subcellular Location: Secreted. Post-translational modifications: N-glycosylated. DISEASE: Defects in IGFBP7 are the cause of retinal arterial macroaneurysm with supravalvular pulmonic stenosis (RAMSVPS) [MIM:614224]. RAMSVPS is an autosomal recessive condition characterized by the bilateral appearance of 'beading' along the major retinal arterial trunks, with the subsequent formation of macroaneurysms. Affected individuals also have supravalvular pulmonic 胰岛素样生长因子结合蛋白7抗体stenosis, often requiring surgical correction. Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain.Contains 1 IGFBP N-terminal domain.Contains 1 Kazal-like domain. Database links: UniProtKB/Swiss-Prot: Q16270.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
胰岛素样生长因子结合蛋白7抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 信号转导 生长因子和**
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid