抑瘤素M抗体
规格：1mg/1ml
英文名： Oncostatin M
别名： Oncostatin M; Oncostatin M precursor; Oncostatin-M; OSM; MGC20461; ONCM_HUMAN.
分子量： 20kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Oncostat
交叉反应：Human, Mouse, Rat,
细胞定位：细胞膜
抑瘤素M抗体产品介绍：background: Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Function: Oncostatin M is a member of the IL6 family of cytokines. Functional receptors for IL6 family cytokines are multisubunit complexes involving 抑瘤素M抗体members of the hematopoietin receptor superfamily. Many IL6 cytokines utilize gp130 as a common receptor subunit. OSM binds to the gp130 receptor subunit and, in association with the leukemia inhibitory factor receptor, induces a proliferative response in permissive cells. OSMR is an alternative subunit (for an OSM receptor complex (a heterodimer of gp130 and OSMR) that is activated by OSM but not by LIF. [Entrez Gene] Subcellular Location: Secreted. Similarity: Belongs to the LIF/OSM family. Gene ID: 5008 Database links: Entrez Gene: 抑瘤素M抗体5008 Human Entrez Gene: 18413 Mouse Entrez Gene: 289747 Rat Omim: 165095 Human SwissProt: P13725 Human SwissProt: P53347 Mouse SwissProt: Q65Z15 Rat Unigene: 248156 Human Unigene: 131422 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
抑瘤素M抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid