微粒体甘油三酯转运蛋白
规格：1mg/1ml
英文名： MTTP
别名： ABL; Microsomal triglyceride transfer protein (large polypeptide 88kDa); Microsomal triglyceride transfer protein 88kD; Microsomal triglyceride transfer protein; Microsomal triglyceride transfer prote
分子量： 97kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MTTP
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Guinea Pig,
细胞定位：细胞浆
微粒体甘油三酯转运蛋白产品介绍：background: MTTP catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. MTTP is required for the secretion of plasma lipoproteins that contain apolipoprotein B. It is positively regulated by cholesterol and negatively regulated by insulin. Defects in MTP are the cause of abetalipoproteinemia. Function: Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B. Subunit: Heterodimer composed of MTTP and of protein disulfide isomerase (P4HB/PDI) (By similarity). Subcellular Location: Endoplasmic reticulum. Tissue Specificity: Liver and small intestine. Also found in ovary, testis and kidney. DISEASE: Abetalipoproteinemia (ABL) [MIM:200100]: An autosomal recessive disorder of lipoprotein metabolism. Affected individuals produce virtually no circulating apolipoprotein B-containing 微粒体甘油三酯转运蛋白lipoproteins (chylomicrons, VLDL, LDL, lipoprotein(A)). Malabsorption of the antioxidant vitamin E occurs, leading to spinocerebellar and retinal degeneration. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Contains 1 vitellogenin domain. Gene ID: 4547 Database links: Entrez Gene: 487873 Dog Entrez Gene: 100734244 Guinea pig Entrez Gene: 100053803, Horse Entrez Gene: 4547 Human Entrez Gene: 17777 Mouse Entrez Gene: 397381 Pig Entrez Gene: 100341961 Rabbit Entrez Gene: 310900 Rat Omim: 590075 微粒体甘油三酯转运蛋白Human SwissProt: P55156 Cow SwissProt: P55157 Human SwissProt: O08601 Mouse SwissProt: Q865F1 Pig Unigene: 195799 Human Unigene: 2941 Mouse Unigene: 81556 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 微粒体甘油三酯转移蛋白（microsomal triglyceride transfer protein，MTP）是一种主要分布于肝细胞、肠上皮细胞中的脂质转移蛋白，存在于细胞微粒体、内质网腔内，在内质网内含量*高，微粒体甘油三酯转运蛋白占总蛋白的0．5％-1．0％,MTTP在甘油三酯转运及极低密度脂蛋白组装和分泌中发挥着重要作用。
产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 细胞生物 **学 信号转导 脂蛋白 新陈代谢
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid