羟基类固醇脱氢酶3α/3α-羟类固醇脱氢酶Ⅰ抗体
规格：1mg/1ml
英文名： HSD3a
别名： 3 alpha HSD1; 3-alpha-HSD1; 3-alpha-HSD; 3-alpha-hydroxysteroid dehydrogenase type I; AK1C4_HUMAN; AKR1C4; Aldo keto reductase family 1 member C4; Aldo-keto reductase family 1 member C4; CDR; Chlordec
分子量： 36kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human 3-alpha-
交叉反应：Human, Mouse, Rat, Horse, Rabbit,
细胞定位：细胞浆
羟基类固醇脱氢酶3α/3α-羟类固醇脱氢酶Ⅰ抗体产品介绍：background: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008]. Function: Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20-alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the羟基类固醇脱氢酶3α/3α-羟类固醇脱氢酶Ⅰ抗体 major excretory route. Subunit: Monomer. Subcellular Location: Cytoplasm. Tissue Specificity: Liver specific. DISEASE: Defects in AKR1C4 are a cause of 46,XY sex reversal type 8 (SRXY8) [MIM:614279]. A disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females. Note=AKR1C4 mutations may act as modifier of disease severity in SRXY8 patients. A splicing mutation resulting in loss of exon 2 has been found in affected individuals also carrying mutation Val-79 in 羟基类固醇脱氢酶3α/3α-羟类固醇脱氢酶Ⅰ抗体AKR1C2 (PubMed:21802064). Similarity: Belongs to the aldo/keto reductase family. Gene ID: 1109 Database links: Entrez Gene: 1109 Human Omim: 600451 Human SwissProt: P17516 Human Unigene: 567245 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
羟基类固醇脱氢酶3α/3α-羟类固醇脱氢酶Ⅰ抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid